2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms
نویسندگان
چکیده
منابع مشابه
Novel chromogenic aminopeptidase substrates for the detection and identification of clinically important microorganisms.
A series of amino acid derivatives 8-10, 42 and 43 have been prepared as chromogenic enzyme substrates in order to detect aminopeptidase activity in clinically important Gram-negative and Gram-positive bacteria. Enzymatic hydrolysis liberates the amino acid moiety and either a 4-aminophenol or a 4-dialkylaminoaniline derivative which undergoes oxidative coupling with 1-naphthol or a substituted...
متن کاملDetection of l-alanylaminopeptidase activity in microorganisms using fluorogenic self-immolative enzyme substrates.
A series of fluorogenic enzymatic substrates that incorporate a self-immolative spacer were synthesised for the purpose of identifying l-alanylaminopeptidase activity in microorganisms in agar media. These substrates resulted in the generation of fluorescent microorganism colonies with Gram-negative microorganisms.
متن کاملCdO nanoparticles as an efficient, mild and recyclable catalyst for the synthesis of 2-aryl benzoxazole derivatives by grinding method
CdO nanoparticles efficiently catalyzes the condensation of aromatic aldehydes with 2-aminophenol at room temperature to afford 2-aryl benzoxazole derivatives by grinding method. The reactions proceed under heterogeneous and mild conditions to provide 2-aryl benzoxazoles in excellent yields (87-97 %) with high purity under solvent free condition. The reaction requires short time (5-23 minutes) ...
متن کاملCdO nanoparticles as an efficient, mild and recyclable catalyst for the synthesis of 2-aryl benzoxazole derivatives by grinding method
CdO nanoparticles efficiently catalyzes the condensation of aromatic aldehydes with 2-aminophenol at room temperature to afford 2-aryl benzoxazole derivatives by grinding method. The reactions proceed under heterogeneous and mild conditions to provide 2-aryl benzoxazoles in excellent yields (87-97 %) with high purity under solvent free condition. The reaction requires short time (5-23 minutes) ...
متن کاملRapid detection of the most important pathogenic microorganisms in water and Food by (Chromogenic media)
Abstract Background and Objectives: Chromogenic media are the newest methods applied for rapid detection of pathogenic microorganisms in drinking water and food from 1998-2008. These Specific media contained the compounds acting as a substrate for microbial enzymes and, according to the type of enzyme, produce specific color. The aim of this study was to introduce the chromogenic media as a pow...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2015
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2015.10.099